Welcome to Zell Labor (ZellLab)!

ZellLab was established to facilitate the needs of cell-based technology in promoting regenerative medicine. Among all targeted goals, we have prepared for you a new concept for anti-aging strategy.

Stem/progenitor cell technology is one of our cutting-edge technologies which is listed on this website. Hopefully, you can find our website resourceful!

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SKIN AGING

The structural integrity and functions of the skin are altered with the passage of time. The chronological intrinsic aging of skin cells may result in a progressive decrease of turnover epidermal time and loss of tone and elasticity of the skin. Moreover, the skin aging is also accompanied by an increased susceptibility to injury and infection, reduced wound healing, wrinkles (rhytides), pigmentary alterations, hair graying and loss, blood vessels weakness, and increased risk of skin epithelial cancers and melanoma. Among the principal environmental factors that may promote the skin-aging process and ultimately carcinogenesis, repeated exposure to solar ultraviolet (UV) radiations is critical. Although the active repair mechanisms and melanin synthesis may protect the skin cells against UV radiation-induced cellular damages, a chronic or cumulative exposure to sunlight may induce several gene mutations and culminate to the development of skin disorders such as epidermal atrophy, psoriasis, keratosis, depigmentation, and dysplasia as well as skin cancer initiation.

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SENESCENCE AND APOPTOSIS

The cellular regeneration of skin epidermis and hair follicles is maintained along with the lifespan of individuals by different adult stem/progenitor cell subpopulations localized within the specialized microenvironments, niches in the basal layer of the epidermis, sebaceous gland, and hair follicle bulge region. These small subpopulations of immature cells endowed with a high self-renewal capacity and multilineage differentiation ability contribute to replenishing the different skin cell lineages, including mature and specialized keratinocytes, sebocytes or melanocytes, in homeostatic conditions or after skin injuries.

A chronic or cumulative ultraviolet (UV) light exposure, inflammation, and oxidative stress on skin stem/progenitor cells and their progenies, usually lead to their dysfunctions via senescence or apoptosis with advancing age. This age-related decline in skin regenerative cells may result in a skin homeostatic imbalance and severe cutaneous disorders. In particular, a long-term exposure of skin cells to environmental insults such as UV radiations and internal metabolic reactions typically generates highly toxic products and reactive free radicals.

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STEM CELL FOR ANTI-AGING

Numerous therapeutic approaches have been developed to restore the skin integrity and functions with advancing age and improve the repair mechanisms after severe injuries. The use of antioxidants, anti-inflammatory and detoxifying agents, calorie restriction and stem cell-based therapies have emerged as the promising strategies to prevent or delay the functional decline or loss of skin-resident adult stem/progenitor cells and their progenies occurring during chronological aging or photoaging. These anti-aging strategies, which may improve the stress resistance and survival of skin regenerative cells, represent the potential therapies to prevent the age-related skin detrimental alterations and disorders such as premature aging diseases, chronic non-healing wounds and ulcers and ectodermal dysplasia.

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FRESH STEM CELL SECRETOME

Since most of the anti-aging patients have adequate endogenous stem cells, therefore stem cell is not necessary to regenerate skin. However, the endogenous stem cells should be accelerated. In this perspective, good stem cell microenvironment should be generated. By introducing stem cell secretome, the good microenvironment can be achieved. Based on latest technology, stem cell secretome has been developed from umbilical cord blood mesenchymal stem cell. The secretome will be prepared fresh upon your request.

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